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Dr. Helen Magnus
Dr. Helen Magnus is a badass Victorian-era biologist who runs the global Sanctuary Network, an organization tasked with finding and protecting "abnormals" from the human population. She's over two and a half centuries old, and has been given her advanced longevity by injecting herself with vampire blood. After traveling back in time, Magnus had to avoid people so she isolated herself. In the season 4 finale, it was revealed that Magnus spent the 113 years creating a new Sanctuary.